Impact of Short- and Long-range Forces on Protein Conformation and Adsorption Kinetics

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We have studied the adsorption kinetics of the protein amylase at solid/liquid interfaces. Offering substrates with tailored properties, we are able to separate the impact of short- and long-range interactions. By means of a colloidal Monte Carlo approach including conformational changes of the adsorbed proteins induced by density fluctuations, we develop a scenario that is consistent with the experimentally observed three-step kinetics on specific substrates. Our observations show that not only the surface chemistry determines the properties of an adsorbed protein layer but also the van der Waals contributions of a composite substrate may lead to non-negligible effects.
6 pages, 5 figures, revised version

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Soft Condensed Matter

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http://salesiana.dossiersoluciones.com/handle/123456789/128999

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/cond-mat/0607384
 http://arxiv.org/abs/cond-mat/0607384

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arXiv