Impact of Short- and Long-range Forces on Protein Conformation and Adsorption Kinetics

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dc.creatorQuinn, Anthony
dc.creatorMantz, Hubert
dc.creatorJacobs, Karin
dc.creatorBellion, Markus
dc.creatorSanten, Ludger
dc.date2006-07-14
dc.date2007-05-16
dc.date.accessioned2026-07-07T08:01:43Z
dc.date.available2026-07-07T08:01:43Z
dc.descriptionWe have studied the adsorption kinetics of the protein amylase at solid/liquid interfaces. Offering substrates with tailored properties, we are able to separate the impact of short- and long-range interactions. By means of a colloidal Monte Carlo approach including conformational changes of the adsorbed proteins induced by density fluctuations, we develop a scenario that is consistent with the experimentally observed three-step kinetics on specific substrates. Our observations show that not only the surface chemistry determines the properties of an adsorbed protein layer but also the van der Waals contributions of a composite substrate may lead to non-negligible effects.
dc.description6 pages, 5 figures, revised version
dc.identifierhttps://arxiv.org/abs/cond-mat/0607384
dc.identifierhttp://arxiv.org/abs/cond-mat/0607384
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/128999
dc.subjectSoft Condensed Matter
dc.titleImpact of Short- and Long-range Forces on Protein Conformation and Adsorption Kinetics
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