Optimal length and signal amplification in weakly activated signal transduction cascades

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Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the characterization of the final outcome. The most efficient design of a cascade for generating sharp signals, is obtained by choosing all the off rates equal, and a ``universal'' finite optimal length.
27 pages, 10 figures, LaTeX file

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Optimization and Control, Molecular Networks, 93D25, 93B99, 92C99

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http://salesiana.dossiersoluciones.com/handle/123456789/69275

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/math/0311357
 http://arxiv.org/abs/math/0311357

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arXiv