Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs

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To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6-10^9 decoy sites? Our analysis of 319 known TF binding motifs clearly demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genome locations; eukaryotic TFs exhibit widespread nonfunctional binding and require clustering of sites in regulatory regions for specificity.
4 pages, 2 figures, expanded Supplementary Methods, Figures and Tables

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Genomics, Biomolecules, Molecular Networks, Populations and Evolution, Quantitative Methods, Subcellular Processes

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http://salesiana.dossiersoluciones.com/handle/123456789/216612

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/0812.3910
 http://arxiv.org/abs/0812.3910

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arXiv