Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs

Simple item page
dc.creatorMirny, Leonid A.
dc.creatorWunderlich, Zeba
dc.date2008-12-19
dc.date2009-01-21
dc.date.accessioned2026-07-07T12:31:55Z
dc.date.available2026-07-07T12:31:55Z
dc.descriptionTo regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6-10^9 decoy sites? Our analysis of 319 known TF binding motifs clearly demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genome locations; eukaryotic TFs exhibit widespread nonfunctional binding and require clustering of sites in regulatory regions for specificity.
dc.description4 pages, 2 figures, expanded Supplementary Methods, Figures and Tables
dc.identifierhttps://arxiv.org/abs/0812.3910
dc.identifierhttp://arxiv.org/abs/0812.3910
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/216612
dc.subjectGenomics
dc.subjectBiomolecules
dc.subjectMolecular Networks
dc.subjectPopulations and Evolution
dc.subjectQuantitative Methods
dc.subjectSubcellular Processes
dc.titleFundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs
dc.typetext

Files

Collections

arXiv