A Dynamical Model of Lipoprotein Metabolism

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We present a dynamical model of lipoprotein metabolism derived by combining a cascading process in the blood stream and cellular level regulatory dynamics. We analyse the existence and stability of equilibria and show that this low-dimensional, nonlinear model exhibits bistability between a low and a high cholesterol state. A sensitivity analysis indicates that the intracellular concentration of cholesterol is robust to parametric variations while the plasma cholesterol can vary widely. We show how the dynamical response to time-dependent inputs can be used to diagnose the state of the system. We also establish the connection between parameters in the system and medical and genetic conditions.
To appear in Bulletin of Mathematical Biology

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Quantitative Methods, Cell Behavior

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http://salesiana.dossiersoluciones.com/handle/123456789/118385

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/q-bio/0610053
 http://arxiv.org/abs/q-bio/0610053

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arXiv