A Dynamical Model of Lipoprotein Metabolism

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dc.creatorAugust, Elias
dc.creatorParker, Kim H.
dc.creatorBarahona, Mauricio
dc.date2006-10-28
dc.date.accessioned2026-07-07T07:30:12Z
dc.date.available2026-07-07T07:30:12Z
dc.descriptionWe present a dynamical model of lipoprotein metabolism derived by combining a cascading process in the blood stream and cellular level regulatory dynamics. We analyse the existence and stability of equilibria and show that this low-dimensional, nonlinear model exhibits bistability between a low and a high cholesterol state. A sensitivity analysis indicates that the intracellular concentration of cholesterol is robust to parametric variations while the plasma cholesterol can vary widely. We show how the dynamical response to time-dependent inputs can be used to diagnose the state of the system. We also establish the connection between parameters in the system and medical and genetic conditions.
dc.descriptionTo appear in Bulletin of Mathematical Biology
dc.identifierhttps://arxiv.org/abs/q-bio/0610053
dc.identifierhttp://arxiv.org/abs/q-bio/0610053
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/118385
dc.subjectQuantitative Methods
dc.subjectCell Behavior
dc.titleA Dynamical Model of Lipoprotein Metabolism
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