VE-cadherin and claudin-5: it takes two to tango

Thumbnail Image

Date

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Description

Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and -catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.

Keywords

Cell Behavior

Citation

URI

http://salesiana.dossiersoluciones.com/handle/123456789/180072

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/0811.4025
 http://arxiv.org/abs/0811.4025
 Nat Cell Biol 10, 8 (2008) 883-5
 doi:10.1038/ncb0808-883

Collections

arXiv