Sensitivity Analysis of Stoichiometric Networks: An Extension of Metabolic Control Analysis to Non-equilibrium Trajectories

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A sensitivity analysis of general stoichiometric networks is considered. The results are presented as a generalization of Metabolic Control Analysis, which has been concerned primarily with system sensitivities at steady state. An expression for time-varying sensitivity coefficients is given, and the Summation and Connectivity Theorems are generalized. The results are compared to previous treatments. The analysis is accompanied by a discussion of the computation of the sensitivity coefficients and an application to a model of phototransduction.
23 pages, 13 figures

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Biological Physics, Quantitative Biology

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http://salesiana.dossiersoluciones.com/handle/123456789/84767

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/physics/0206075
 http://arxiv.org/abs/physics/0206075

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arXiv