First passage times of pulling-assisted DNA unzipping

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We investigate the voltage-driven transport of hybridized DNA through membrane channels. As membrane channels are typically too narrow to accommodate hybridized DNA, the dehybridization of the DNA is the critical rate limiting step in the transport process. Using a two-dimensional stochastic model, we show that the dehybridization process proceeds by two distinct mechanisms; thermal denaturation in the limit of low driving voltage, and direct stripping in the high to moderate voltage regime. Additionally, we investigate the effects of introducing non-homologous defects into the DNA strand.
7pp, 3 figures

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Statistical Mechanics, Soft Condensed Matter

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http://salesiana.dossiersoluciones.com/handle/123456789/24079

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/cond-mat/0406006
 http://arxiv.org/abs/cond-mat/0406006

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arXiv