Cable dynamics applied to long-length scale mechanics of DNA

Thumbnail Image

Date

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Description

This paper introduces the use of cable dynamics models as a means to explore the mechanics of DNA on long-length scales. It is on these length scales that DNA forms twisted and curved three-dimensional shapes known as supercoils and loops. These long-length scale DNA structures have a pronounced influence on the functions of this molecule within the cell including the packing of DNA in the cell nucleus, transcription, replication and gene repair. We provide a short background to the mechanics of DNA and suggest the logical connection to the mechanics of a low tension cable. A computational model is then summarized and example results are presented for DNA supercoiling and looping.
14 pages, 7 figures, An invited keynote speech, in CD-ROM Proceedings of Sixth International Symposium on Cable Dynamics, Charleston, SC, 19-22 Sept, 2005

Keywords

Biological Physics, Chemical Physics, Computational Physics

Citation

URI

http://salesiana.dossiersoluciones.com/handle/123456789/124527

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/physics/0702197
 http://arxiv.org/abs/physics/0702197

Collections

arXiv