Coupled dynamics of DNA-breathing and single-stranded DNA binding proteins

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We study the size fluctuations of a local denaturation zone in a DNA molecule in the presence of proteins that selectively bind to single-stranded DNA, based on a (2+1)-dimensional master equation. By tuning the physical parameters we can drive the system from undisturbed bubble fluctuations to full, binding protein-induced denaturation. We determine the effective free energy landscape of the DNA-bubble and explore its relaxation modes.
REVTeX4, 4 pages, 5 figures, revised version

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Biomolecules, Statistical Mechanics

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http://salesiana.dossiersoluciones.com/handle/123456789/88487

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/q-bio/0411053
 http://arxiv.org/abs/q-bio/0411053

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arXiv